Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Keep around people who like to remind you how smart you are, and stay even though they think you are a dick.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Do you often feel gloomy and down in the dumps?
3. 《间谍之桥》(Bridge of Spies)。几年前，史蒂文·斯皮尔伯格(Steven Spielberg)进入了殿堂级导演的行列，从安德鲁·萨里斯(Andrew Sarris)所谓的“美国电影”中借鉴了最崇高的形式——这部影片中他仍然保持水准。
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
5. "Dexter" (3.1 million)
Actively expanding China's opening up to the world
Trends and targets in antiviral phototherapy
“Yao represents the new wave of wealth creation by financial investments in China,” said Rupert Hoogewerf, who compiles the annual list.
This is second major English-language role for the French actress, who co-stars opposite Daniel Craig in Skyfall as the enigmatic Severine. The movie opens Nov. 9 in North America but already is shattering records internationally.
Employers have stepped up their hiring recently, adding 171,000 jobs in October and an average of 157,000 a month so far this year. That's a better pace than last year and the strongest job growth since 2006, Labor Department data show.[qh]
The biggest story of the festival had nothing to do with films. It was about shoes. On Tuesday trade magazine Screen reported that a group of women had been denied access to a screening of Todd Haynes' Carol because their footwear – flat shoes with rhinestones – was unsuitable for the red carpet. Further tales came tumbling forth, social media erupted in indignation and soon enough we were soon dealing with a fully fledgedscandale. The Cannes press office rushed out a garbled statement: “Rules have not changed throughout the years (Tuxedo, formal dress for Gala screenings) and there is no specific mention about the height of the women's heels as well as for men's. Thus, in order to make sure that this rule is respected, the festival's hosts and hostesses were reminded of it.” Well, that cleared that up. Perhaps wisely, press screenings are exempt from any dress code: scruffy journalists are free to ascend the Palais' steps in flip flops and trainers.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
No. Wall Street strategists’ predicting that the US government’s 10-year borrowing costs will climb above the 3 per cent mark in the coming year is as much a staple of the Christmas period as awkward office parties. This year the forecasts look more likely to be fulfilled, given a withdrawal of quantitative easing and the US tax cut. However, the seismic, secular forces pinning down both inflation and long-term bond yields remain in place and are still underestimated. The Federal Reserve will raise interest rates at least three times in 2018, but the 10-year yield will not breach 3 per cent.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
5. bedazzled / a . 眼花缭乱的。
ACE2 as a potential therapeutic target for pandemic COVID-19
Romance was different then - with no computers, letter writing was the only way to stay in touch and remains more romantic than emails, he said.
Diagnostic technologies for COVID-19: a review
The list also has some movies that earned awards at the 67th Berlin International Film Festival in February, such as the best movie winner On Body and Soul and best director winner The Other Side of Hope, by Aki Kaurismaki of Finland.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Initial success was achieved in supply-side structural reform.
The Magic are the single-most mystifying team in this entire exercise. They make little sense on paper or on the court.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
The programme is ranked second for career progress three years after graduation. Tiemba’s graduates number only about 250 so far, making them an elite group.— LaurentOrtmans
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
“You can choose to spend the time however you like,” he wrote, suggesting people “go travelling, pursue a philanthropic project, spend quality time with family or simply take time out to recharge and refocus”.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Song “Unforgettable” (Li Guyi, Zhang Yingxi and students from Confucius Institute)
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Apple (AAPL, Fortune 500) announced that it would put $30 billion of its cash toward share repurchases. The news made investors happy: The stock popped, and even a week later was up 12% relative to the S&P over that same 7-day period. The buybacks were part of a larger $130 billion capital return program that the company said would extend through 2015.
Antiviral drug discovery: broad-spectrum drugs from nature
*最佳综艺导演：瑞安?麦克福(Ryan McFaul)，《艾米?舒莫的内心世界》(Inside Amy Schumer)
《广告狂人》对时装的影响体现在品牌的发展当中，例如香蕉共和国(Banana Republic)就推出了《广告狂人》系列（这个系列是与该剧的服装主管贾妮·布赖恩特[Janie Bryant]联合设计的），而且很多心照不宣的地方在设计中更加随处可见：裁剪和印花，褶边和接缝；它的影响渗入了在秀台上普遍存在的一种鲜明理念：如果你缺乏灵感或者产生了审美怀疑，就去回顾60年代吧。
3. Portugal is entirely powered by renewable energy for four days
Influenza neuraminidase: A druggable target for natural products
The ranking of 95 schools, up from 90 last year, includes nine institutions, from seven countries, that were ranked for the first time. Frankfurt School of Finance and Management in 41st place is the year’s highest new entrant. The German school has one of the most gender-balanced programmes, with women accounting for 49 per cent of students.
《为奴十二载》(12 Years A Slave)：这是一部奇特的文娱片，令人震动、悲伤。本片导演史蒂夫?麦昆(Steve McQueen)大胆拍摄了一个关于美国奴隶制时代的故事，发人深省，是一部迎合主流观众口味的佳作。这部影片证明了艺术的力量，同时说明影迷们在他们选择观看的电影中渴求影片的本质和意义，这一点也令人振奋。该片编剧为约翰?里德利(John Ridley)，主演包括切瓦特?埃加福特(Chiwetel Ejiofor)、露皮塔?尼永奥(Lupita Nyong'o)、迈克尔?法斯宾德(Michael Fassbender)等人。
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
“It is exceptionally unlikely that we would be witnessing a record year of warmth, during a record-warm decade, during a several decades-long period of warmth that appears to be unrivaled for more than a thousand years, were it not for the rising levels of planet-warming gases produced by the burning of fossil fuels,” Michael E. Mann, a climate scientist at the Pennsylvania State University, said in an email.
They say that it is especially risky to use the same password for entertainment sites as for email and social networking accounts.
The role of biosensors in the detection of emerging infectious diseases
1. Apple. Brand love: 57% / Rank: 32
Quantitative determination of mechanical stability in the novel coronavirus spike protein
For the first time in six years, a new challenger has topped the FT’s ranking of executive MBA programmes.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Businesses are already responding: Job openings in November hit the second highest level in 14 years. In another telltale sign, people are quitting jobs at the fastest rate in five years. Research shows that people who quit one job for another typically do so because they are offered higher pay.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
The worst of 2015
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
We’ve all had them: bosses and managers who make our work lives terrible and couldn’t manage a stack of paper clips, let alone a team of employees. I’ve written about the traits that make for bad bosses before, and in that article, a thoughtful commenter came up with his own list of what makes a good boss。
Inhibition of SARS coronavirus helicase by bismuth complexes
It’s ironic that in a country as populous as China, a meme about loneliness would be so popular. This seemingly irrational line has been repeated in every possible permutation, on every possible occasion, e.g. “What big brother is reading not a book, but loneliness.”
The Producer Price Index (PPI), which gauges factory-gate prices and is a major indicator of economic briskness, rose by 6.3% in 2017, compared with a minus 1.4% for 2016, reversing the trend of continual decline since 2012.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
The UK’s Warwick Business School recorded the best progression at the top, moving up from 16th to ninth place, while the Shanghai Advanced Institute of Finance (Saif), based at JiaoTong University, enjoys the bestprogression overall, jumping from 28th to 14th place.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
The number of students who will study abroad after graduation has also seen a drop, down from 4.8 percent last year to 3.4 percent.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
The United Kingdom ranks No. 3 overall. It ranks No. 4 in Power and No. 5 in Cultural Influence.
自该学校的国际管理学硕士(International Master in Management)项目首次被纳入榜单以来，该学校的排名在过去两年上升31个位置。
Much joy to you in the up coming year. May the warmest wishes, happy thoughts and friendly greetings come at New Year and stay with you all the year through.让温馨的祝愿、幸福的思念和友好的祝福，在新年来到你身边，伴你左右。
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
《傲骨贤妻》(The Good Wife)：艾丽西娅(Alicia)的秘密暧昧对象威尔（Will，乔希·查尔斯[Josh Charles]饰）在第五季末死去，CBS频道的这部性感法庭剧似乎要完蛋了，但是第六季却似乎充满了疯狂的能量——艾丽西娅初露头角的政治竞选、新旧公司的权力之争、合伙人卡里(Cary)的棘手法律事务。艾丽西娅不再那么完美，《傲骨贤妻》因此更好看了。
That pushed the state share of total investment for the year to date down marginally to 36.6 per cent, still the largest share since 2011 and reflecting the outsize role of government spending in sustaining economic growth during 2016.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
A member of staff at the Yizheng Museum told MailOnline that the bronze item had been found inside the tomb of an aristocrat in the West Han Dynasty (206 BC–8 AD) the first part of the Han Dynasty.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
3. Jia Junpeng, your mom wants you to go home for dinner.”
But whether another hit product can emerge to fend off questions about Apple’s life after Jobs, Mr Cook learnt long ago to be patient and trust his instincts, just as he did when he ignored the doubters to join the then-struggling company in 1998.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
北京正努力在年底前完成《区域全面经济伙伴关系协定》（Regional Comprehensive Economic Partnership，简称RCEP）。该协议长期以来被称为中国面对《跨太平洋伙伴关系协定》（Trans-Pacific Partnership agreement，简称TPP）的对策，以及代表了中国争取区域贸易霸权的努力。
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Students were then asked to move the dispenser to the teachers' office where teachers then called the police.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Although the average punctuality rate of the surveyed airports rose 7% year-on-year to 70.4% in 2016, the average delay time was 33 minutes.
Armistice Day became an official U.S. holiday in 1938, and remained so until 1954, when it was renamed Veterans Day in the aftermath of both World War Two and the Korean War. It is separate from Memorial Day, which is observed on the last Monday in May and honors servicemen and women killed in war.
We will make solid efforts to pursue the Belt and Road Initiative.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Set in 1950's London, Reynolds Woodcock is a renowned dressmaker whose fastidious life is disrupted by a young, strong-willed woman, Alma, who becomes his muse and lover.
The Belty is great that it uses technology to track fitness, water intake, and posture, but for $395, you might be better off getting the same in a stylish smart watch or activity tracker.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
The Shape of Water
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Meanwhile, there are other factors holding back the Asian ETF market that some sceptics fear will hold back development of the retail side.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
the Dutch lender that is a leading financier to farmers and agribusinesses around the world.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
The 54-year-old has already said he wants Bain to be recognised as a go-to provider of digital expertise. The question is whether this will be achieved through acquisitions, poaching teams or retraining the existing workforce.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
The Death Proof star's early success was on the independent film circuit. But then she met Harvey Weinstein in a hotel room and it is there that she alleges he raped her.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Identity, as academics define it, falls into two broad categories: “achieved” identity derived from personal effort, and “ascribed” identity based on innate characteristics.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
“The impact of lower prices on the slide in profits is worsening,” he said.
A facile assay for rapid detection of COVID-19 antibodies
Mila Kunis placed second on the list, followed by Kate Upton, pop star Rihanna and Emma Stone.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Last year, only 930,000 of the 1.39 million qualified finally entered the exam halls.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
BACKSTROM (Fox, Jan. 22) Last year, Fox tried a show about a self-destructive lawyer (“Rake,” starring Greg Kinnear) that was based on an Australian TV series. That didn’t work, but now the network is trying a show about a self-destructive detective (played by Rainn Wilson of “The Office”) that’s based on a series of Swedish novels. The show was created by Hart Hanson, who was responsible for the Fox series “Bones,” but in the pilot Mr. Wilson’s Backstrom looks a lot more House-like than Bones-like.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
A person walks through snow Tuesday in Belington, West Virginia. Superstorm Sandy buried parts of West Virginia under more than a foot of snow on Tuesday.
Fuel for this latest burst of Tesla mania came from none other than Chairman and CEO Elon Musk in comments he made during an analyst call on July 31. The big news wasn’t that Tesla reported higher production for the second quarter and beat earnings estimates again.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
“I saw a woman die and I saw the president of the United States refuse to unequivocally condemn the people who killed her.”
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Warm greetings and best wishes for happiness and good luck in the coming year.衷心祝福来年快乐、幸运！
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
But only 14,000 tourists took advantage of the visa-free stopover, according to the Beijing General Station of Exit and Entry Frontier Inspection, well short of the 20,000 target officials had previously predicted.
Anti-HIV drug repurposing against SARS-CoV-2
Tesla has an order backlog of $226 million. At the production run rate of 1000 cars a week expected at the end of 2014, that translates to a 30-week backlog.
Length-scale dependence of protein hydration-shell density
Chinese imports fell 18.8 per cent in October from the same month a year earlier, a slight improvement from the 20.4 per cent year-on-year fall in September. Sharply lower prices of oil and other commodities also helped scythe the bill.
That will require different skills — notably a clearer vision among leaders of their organisation’s shared purpose. The dilemma of how to lead “teams” of robots and humans will become even more pressing this year.
Here are five things consumers and investors can count on (probably) in 2015:
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
For example, taxi drivers who take a detour or refuse passengers can also be fined a maximum of 2,000 yuan.
Warriors winning title was inevitable
As the cameras cut away to the cast and crew of "La La Land" hugging, Beatty could be heard saying something such as, "It says Emma Stone," with Dunaway replying, "What?" As the La La Land cast were walking on stage to accept the accolade, a stagehand standing in the wings could be heard saying "Oh ... Oh my god, he got the wrong envelope".
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In fact, one ancient saying was, "ifyou have Kucha, only one percent of the states in the Western Frontiers remain unsubmissive."