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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

China’s reserves have fallen for nine of 11 months this year and stand at $3.43tn, as investors sell renminbi assets to protect themselves against depreciation and the central bank sells dollars from its reserves to curb renminbi weakness. Falling interest rates in China and expectations of an imminent rate rise by the US Federal Reserve have also fuelled outflows. Reserves rebounded mildly in October, suggesting outflows had diminished.
以下是其中最值得期待的10部,我们相信这10部电影都将成为票房宠儿,值得反复欣赏。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
From the themed collection: 一季度河北省新增减税96.52亿元
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

奖项:尽管大众的高尔夫GTI先拔头筹,但偏向自家人的2015年北美汽车大奖的评审员们还是对福特的野马和F-150皮卡不吝溢美之辞。
Andy Murray's US Open victory and Olympic gold medal helped him to become the most searched-for British Olympian.

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

Lucy Kay 成为亚军,而正太组合 Bars and Melody 位列第三。

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

The Great Recession had devastating effects across the U.S. and few places were as hard hit as Arizona. The state was booming on the strength of its tourism and real estate markets during the 2000s. Median home prices jumped 70% between 2003 and 2006—only Nevada had bigger gains—fueling more building and construction jobs. Monthly unemployment was at 3.5% through much of 2007. But then the bottom fell out. Home prices plummeted more than 50% from their peak and 6% Arizona properties received foreclosure filings in 2009. Unemployment stubbornly remained in double-figures for most of 2009 and 2010 and only Nevada lost a higher percentage of jobs over the last five years. Household incomes declined at the fastest rate in the country since 2008.

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

“It’s na瘀攀 not to recognize we’re at a pretty serious moment,” said Anthony Crichton-Stuart, director of the London dealer Agnew’s. “There has been a massive taste shift. But when a good old master does come up at auction and it is priced correctly, you do get some excitement.”
None of these potential clouds appear to darken the sunny view from Tesla headquarters in Palo Alto. Tesla is sticking with its middle term goal of building 500,000 cars a year by 2020. Much will depend on the ability of the Model X to maintain the current momentum – and mystique. Tesla has steeply ramped up spending on capital expenditures and R&D to make sure the launch, already a year behind schedule, is a success.
4. Precious metals: 'Going dark! Economic cycles point downward'
追踪中国服务业增长的财新PMI指数将于下周二发布。

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

The piece was taken away for laboratory testing, and the Spielman family only received a phone call this month telling them the amulet had been identified.
Aoki-san is a pleasure to work withon storyboard. With Aoki-san on the team it feels like a sure thing. The visionof these animations will be perfect.
查斯特·班宁顿
最近的例子也比比皆是,从乌戈.查韦斯(Hugo Chávez)到欧尔班.维克托(Viktor Orban)和弗拉基米尔.普京(Vladimir Putin)。

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

智联招聘最近的一份调查报告显示,在参与调查的2016届应届毕业生中,毕业后选择创业的比例为仅仅只有3.1%,而2015年的比例是6.3%。

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

和所有大学生一样,埃文o雷喜欢使用表情符号。但让他恼火的是,没有什么表情符号能够让他向圣母大学的同学表达自己对该校橄榄球队战斗的爱尔兰人的自豪感。于是,他和肖恩o欧布莱恩一起创办了一桩小生意,以弥补这一空白。这款名为TextPride的产品从体育和娱乐世界中获得图像授权,然后将其打包成贴纸出售。比如,在Kik这样的短信应用中,用户可以花1.99美元买一包迪斯尼电影《冰雪奇缘》的贴纸。

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

达洛伊西奥解释道,自然语言处理有统计学和语义学两种方法,语义学系统试图解析文章的真实含义并对其进行简洁的译介。而统计学系统──设计Summly所采用的方法──无需这一过程;该系统保留词汇和句子的完整性,并通过运算从全文挑选出最具概括力的内容。它将每个句子或词汇进行分类、排序,以便挑出编入摘要的内容。这一过程极依赖数学计算,考量的是频率和分布,而非词语的含义。
她和妹妹都是通过家庭辅导接受教育的。她的妹妹也出演了《Dance Moms》。去年,以两姐妹的名字创建的时尚品牌The Maddie & Mackenzie Collection问世。

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

7. Smart cookie oven
“Obviously, a single year, even if it is a record, cannot tell us much about climate trends,” said Stefan Rahmstorf, head of earth system analysis at the Potsdam Institute for Climate Impact Research in Germany. “However, the fact that the warmest years on record are 2014, 2010 and 2005 clearly indicates that global warming has not ‘stopped in 1998,’ as some like to falsely claim.”

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

Luckily, the singles are only half the story with Reputation. On "Dress," she's high on the rush of a new romantic thrill; on "New Year's Day," she's trying to figure out what she has after the party's over.
‘Can’t fault, I was thinking “go on boys”,’ Alesha smiled.

Graphical abstract: Diagnostic technologies for COVID-19: a review
From the themed collection: 2013年建材行业进出口形势展望
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

There are 15 Chinese brands in the top 100, one more than last year and a sharp rise on a decade ago, when China Mobile was the only Chinese brand.
If you’re looking for a free CRM system, Zoho is probably the one for you. Why? It comes down to the integration possibilities. For example, Zoho integrates with JotForm and Unbounce simply by adding your API key. This means that within seconds, web leads will automatically be sent to your CRM. Pretty powerful for being free.
这是今年最精致的浪漫电影与最尖锐的反浪漫电影,均来自美国电影界最缜密的聪明人。两部影片之间的关系最好用一首威廉·布莱克(William Blake)的诗歌来总结——《土块与卵石》(The Clod and the Pebble)。
4. 蕾哈娜

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

6. Smart refrigerator

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

针对那些对比较世界各地的学校有兴趣的学生,《美国新闻与世界报道》近日发布了第四版全球最佳大学年度排行榜。
“I?.?.?.?learnt to interact with people from other cultures and other places in society,” noted one Swedish graduate.

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

立场:呼吁结束政府停摆局面

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

This post is in partnership with Time. The article below was originally published at Time.com

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

Industrial production expanded 1.4 per cent month-on-month in October, the quickest pace since a 4.1 per cent rise in January. It was better than the 1.1 per cent gain in September, but still fell short of economists' expectations for a gain of 1.8 per cent.
But the crash hit. The economy tanked. The recession lasted 30 months. Wall Street lost over $8 trillion of our retirement money. In the first decade of the 21st century, from the 2000 dot-com crash till 2010 disaster Wall Street's had a negative inflation-adjusted performance. Today Wall Street's returns are just barely beating inflation. No wonder investors feel cheated by Wall Street's casinos.
Hailed as one of the greatest films of all time, Taxi Driver tells the story of a depressed ex-Marine who attempts to assassinate a senator after being rejected by a woman he admires. While the titular taxi driver, Travis Bickle, lives a chaotic life filled with drug dealers and prostitutes, his story was never meant to be an unrealistic fantasy. Rather, it meant to expose the very real warning signs of a would-be gunman.
时报影评人曼诺拉·达吉斯(Manohla Dargis)与A·O·斯科特(A. O. Scott)分享他们挑选的年度最佳电影。

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

在本届达沃斯世界经济论坛(World Economic Forum)盛大闭幕会议上,与会者承认风险的存在,认为缺乏有效管理的新兴市场很容易受到危机冲击,但他们最终得出的结论是,前景是多年来最为光明的。
如今,蓬勃发展的互联网经济在支撑我国信息技术(IT)行业财富增长方面正发挥着越来越重要的作用。
201103/129769.shtmlEveryone tells a white lie on occasion, it’s just a question of why. Some white lies save relationships, some ease a hectic situation, and others buy us time. We all do it, so there is no reason to deny it. As long as we aren’t hurting others or breaking the law, these innocent lies can make life more pleasant. Most of these white lies only stretch aninterpretation of what the truth actually is anyways. Here’s a list of the 10most common white lies and why we tell them.
Against: There was no love from the New York nor LA critics.
《战地神探》(Foyle’s War),acorn.tv,2月2日播出。去年流媒体服务网络Acorn TV放完了《大侦探波洛》(Agatha Christie’s Poirot)的最后三集,如今又带来另一部传统英国推理剧,这部超级剧集在英国已经拍到第九季,在美国还是首次播出。迈克尔·基臣(Michael Kitchen)在剧中饰演克里斯托弗·弗伊(Christopher Foyle),一位可敬而又狡黠的侦探,这部剧多年来从一部“二战”后方警探剧演变成勒卡雷(le Carré)式的冷战惊悚剧。新的几集中有纽伦堡审判以及英国在巴勒斯坦所扮演的角色。

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

没有什么事情能像太阳躲在月亮后面那样,把人们聚集在一起。
Create a mood board for inspiration, including quotes and pictures that will invigorate your creative juices. You might even want to change it up once and a while if you have a major project due or need fresh ideas. Art or wall décor can also add a creative touch to your workspace. We recommend the 3 in 1 Board, $19.95, at CB2.com (pictured above).

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

enter进入+prise进入抓住[目标]→事业;进取心

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

1. Hokkaido, Japan-Though known primarily to the outside world for its ski resorts and powdery snow, Hokkaido's year-round beauty might soon become a more familiar sight to foreign visitors. The new bullet-train service from Tokyo should help.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

……一边说从来不会让人看到他流汗,一边汗流不止。
vt. 打斗
英国新人结婚模仿“怪物史瑞克”(图)
怎样写简历?

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
From the themed collection: 海螺水泥逆势扩产陷租地采矿纠纷
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

Outbound investment for the period totalled $86.3bn, according to the Ministry of Commerce.
9)做得不错:毫无疑问,这有点陈词滥调的味道。有时,仅说一句“谢谢”还不够。人们想知道他们的工作完成得是否出色,也想知道为什么他们工作干的出色。毕竟,他们为项目流了太多的汗水,倾注了太多的心血。他们需要知道自己的工作很特别且是有意义的。
在10月份的第三场总统大选辩论中,两位总统候选人没教养地拒绝与对方握手问好或道别。
There are, for example, clear differences in the way the products are pitched to investors in the US and Asia. A high proportion — some estimate 90 per cent — of funds in Asia are commission-based. This disadvantages ETFs because they are openly traded on stock exchanges and are not structured to pay commissions to banks, brokerages or financial advisers that might recommend them, unlike the mutual fund industry in the region.

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
From the themed collection: 南京黏土砖瓦窑退出历史舞台
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

单词affected 联想记忆:
麦高恩出生于多配偶制的邪教家庭,少年时离家出走。

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

Fifteen Chinese nationals have been charged with developing a fraud scheme in which they paid imposters to take entrance exams, including the SAT, and gained acceptance to elite American colleges and universities, the US Department of Justice said on Thursday. Conspirators were paid up to $6,000 each time they used counterfeit Chinese passports to trick test administrators into thinking they were the person who would benefit from the test score, a federal grand jury charged.重点单词
n. 外表,外貌,出现,出场,露面
IDC认为,中国人可支配收入的增加导致了消费的增加,从而推动了国内手机市场的快速增长。
Whether China opens the stock floodgates or not will be a major price-driver in cotton and sugar — and potentially also in corn, soyabean or vegetable oil — markets in 2017, the bank said in its report.
petr石头,oleum油-石油

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
From the themed collection: 买建材,这些陷阱你遇到过吗?
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

vi. 打结
产险公司利润同比下降43.49%,至336.57亿元人民币。寿险公司利润下降65.60%,至541.84亿元人民币,再保险公司利润下降58.79%,至30.68亿元人民币。
n. 规章制度,草案,协议,外交礼仪

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

中国演员吴秀波于日前被指派担任2017中澳旅游年形象大使。
May the joy of New Year be with you throughout the year.愿新年的快乐一年四季常在。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

While people in first-tier cities are under more pressure, smaller cities may not be the ideal place to live either, according to the 2016 Annual Report on Social Mentality of China by the Chinese Academy of Social Sciences.
As US ETF assets under management passed the $3tn mark this summer, AUM in the Asia-Pacific industry just managed to creep over $350bn.
Hua Xu Yin is about a princess who sacrificed her life for the country but later was saved and began her own adventures with another name. It is also a TV series adaptation of an online novel of the same title written by Tang Qi. The series premiered in July 2015, staring Lin Yuan and Zheng Jiaying. However, it did not get as much attention as its rivals. According to the online critics, the lead roles and their costumes were not appealing enough in the adaptation.

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
From the themed collection: 诸葛找房获投B轮1.5亿人民币融资
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

She has modelled for numerous clothing companies including Glitzy Girl, Sally Miller and Purple Pixies and featured in magazines including Teen Vogue, Cosmopolitan, Elle and Seventeen.
线索可能隐藏在价格之中:H股很便宜。H股指数市盈率为7倍,低于西班牙(该国失业率达到22%)、巴西(该国依赖大宗商品,因而也依赖中国)以及受中东乱局影响的土耳其和埃及。
PBS' 'Vietnam War' series receives a special award.

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

18. Most Interesting Apology (tie) On Nov. 18, The Hollywood Reporter disgorged a 1,200-plus word apology for not including any nonwhite performer in its Oscar actress round table. Soon after, the director Alex Proyas and Lionsgate apologized for the lack of diversity in the cast in their new movie “Gods of Egypt.”

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

Democracy is at bottom a civilised form of civil war.

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

The refugees have streamed into Greece, Bulgaria, Italy, Spain, Malta and Cyprus during 2015, with a huge majority -- over 800,000 -- arriving by sea in Greece. About 3,600 died or disappeared trying to make the perilous Mediterranean Sea crossing between North Africa and Italy.
The biggest falls in brand values include oil and gas companies, still suffering from low commodity prices, and banks, which face growing competition from rival payment systems such as PayPal — whose brand value increased by 35 per cent (see story page 2).

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

时间:2009-07-16 编辑:vicki
adj. 有营养的,滋养的
有的时候,老板挺糟糕的。但如果你觉得你的老板一直很差劲,占用了你的时间,是的,你该去找一份新的工作了。
The hunt for his body began in earnest in 2012 when archaeologists working on historical accounts and geographical clues started to dig beneath the municipal carpark on the spot where Greyfriars was, and found the skeleton.

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

麦高恩说“让女性发怒还很难”,MeToo支持者“为自己编写了一部小说”,并没有直面好莱坞的本质。
2)我相信你的判断:这句话的言外之意:“你征得了我的许可。我信任你。好吧,去做吧。”听到这样的话,是不是感觉很振奋?我保证你会为说这种话的人赴汤蹈火,因为这些话让人感觉如此振奋。你的员工也罢,你的同僚也罢,效果没有区别。

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

由于合并后的航空公司通常继续分别公布航班延误统计数据,我们可能需要几年时间,才能看到全新美国航空公司在假日旅行方面表现如何。
但是以一种最好的方式。

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

吉迪恩拉赫曼(Gideon Rachman)

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

Mr. Russell's 1970s Abscam fictionalization 'American Hustle' had the better night overall, winning acting awards for Amy Adams and Jennifer Lawrence. Best picture was the only award for '12 Years a Slave,' which came in with seven nominations, tied for the most with 'American Hustle.'
James Kynge
For both, opponents are enemies rather than fellow citizens who think differently.
The decaying feet, some dating back to 1967, were being 'cleaned up', plumped up and whitened at the 'foul-smelling' plant using bleach and other chemicals, before being prepared for sale.

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

卓越雇主排名:32
谁都记得几个月前,哈里王子因为媒体对其女友梅格汉·马克尔的猜测而发表了出人意料的公报。

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

全国工商联汽车经销商会数据显示,自2014年进口现代中国经销商网络已经缩减了一半。
The film version of the popular television series "Legend of Sword and Fairy", also known as Chinese Paladin starts shooting in Zhejiang Province today.
体育在热门趋势搜索排行中占据了优势地位,对2012欧洲杯和奥运门票感兴趣的人最多,排名超过了休斯顿和凯特王妃。

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

You'd probably never think that a belt could be integrated with artificial intelligence, yet Belty managed to do it and make it seem stylish. The Beltyautomatically makes you think, "why do I need this?" Then your second thought will probably be, "what if it's hacked and they make it so tight I can't breathe?" The first question is rational; the second one is far-fetched — but if it makes you think twice about buying this product, that's not a bad thing.
The impact of sluggish growth on year-end payouts may have peaked in 2015, however, when 66 per cent of white-collar workers received no year-end bonus. And the 2016 level actually represents an improvement from 2014, when 61 per cent had to go without.
deprivation

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
From the themed collection: 机构预计明年降价楼盘或将增多
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

在纽约举办了多次其标志性的时装秀之后,内衣品牌维多利亚的秘密又来到伦敦、巴黎、戛纳和洛杉矶举办维密秀,而在2017年,该全球女士内衣行业巨头来到了上海。
The punctuality rate of China's major airports is still far from satisfactory, according to the latest report published by local aviation statistic company VariFlight.

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

研究人员写到,对于1700年前的中国朝代来说,如果能征服并有效的管理龟兹的话,那么他们就能够控制住西域所有的绿洲城邦。
香港科技大学(Hong Kong University of Science and Technology)和凯洛格管理学院(Kellogg School of Management)合办的中美EMBA项目重新夺回英国《金融时报》100个最佳EMBA项目排行榜的冠军宝座。
IDC believes that the rising disposable income of Chinese people has resulted in greater consumption, which contributed to the rapid growth of the domestic smartphone market.

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
From the themed collection: 绿色建筑:复合建材唱主角
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

And while there is still a long way to go before airplanes designed and made in China compete on the world stage with the likes of the Boeing 737 or Airbus A320, the momentum is there, and the country’s aerospace industry is entering a new phase of development and maturity.
Gitanjali said she wanted to further refine the device so it could eventually go on the market.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

尽管该片被洛杉矶影评人协会评为最佳剪辑奖,但却没有受到纽约影评人的重视。它的势头会逐渐减弱吗?
Talking to Town & Country, Industry Kitchen Executive Chef Braulio Bunay said he was inspired to create the pizza by the city's Financial District, which he described as 'the epitome of decadence'.
Morocco is home to nine UNESCO World Heritage Sites, mainly ancient towns and old city ruins, making it a decent choice for history lovers.

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

WASHINGTON (MarketWatch) — The U.S. economy finally got a big jolt of energy in 2014 after the lamest recovery since World War II. And 2015 is shaping up to be an even better year.

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

10.Selfie Sticks
The fall in demand for industrial bulk commodities was particularly pronounced. Huge oversupply in China’s real estate and manufacturing sectors has damped investment in new capacity in recent months, denting demand for all kinds of raw materials.

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

We took further steps to implement the Internet Plus action plan and the national big data strategy.
In the season of joy I present my sincere wishes and kind thoughts. May the kind of New Year outshine all the rest.

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

In early 2005, Stone and her co-founders Elisa Camahort Page and Jory Des Jardins noticed that there were countless women blogging, but mainstream media rarely linked to their posts. The trio decided to host a grassroots conference that year and attracted sponsors like Google and Yahoo. It quickly sold out and soon after, they launched BlogHer.com. The publishing platform turned blogging into a lucrative business for many women -- it paid $25 million to 5,000 of its bloggers between 2009 and 2012 -- and now reaches an audience of 92 million.
据西藏扶贫办公室透露,位于中国西南部的西藏自治区,去年共有15万农村居民脱贫。

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

祝好运、健康、佳肴伴你度过一个快乐新年。
champion

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

此外,菲亚特一款引擎不仅首次进入《沃兹汽车》十大引擎榜单,而且还是一款电动发动机,这就是起亚500E所使用的83千瓦发动机。遗憾的是,该车只在加利福尼亚州发售,但是如果汽油价格上涨至每加仑4.00美元大关或以上,市场力量可能说服这家汽车生产商进行更大范围的分销。

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

The U.S. Congress and the media will go berserk when Goldman announces the size of its 2009 bonus pool. But the outrage will be brief and of little lasting consequence. The 'hate Goldman Sachs' story has been running just too long.
China has broken into the world's top 25 innovative economies for the first time, thanks to investments in education and research and development that have translated into new patents and licenses, a study said on Monday.
4.Virtual Assistant: 17.6 percent increase
1、拖延

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

007系列电影主题曲第十名:雪莉·巴赛--《永远的钻石》

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

vi. 领先
8. Get Inspired
但是他告诉华盛顿报的记者他依然很希望能够读到这封信,毕竟这封信是当时的纯真、关切和真诚的见证。

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

“我们一直用很高的标准要求自己”,库里赛后表示。“我们在第三节没有给他们防守端施加压力,草率地结束了我们的进攻并且给了他们机会。有很多需要我们继续提高的地方,当然,每个人都愿意在赢球的同时接受教训。”
很难想象《迷失》中若是没有杰克·谢帕德作主角,这部剧会变成什么样。大概只有编剧真的这样写了,我们才会知道答案吧。美国广播公司引进这部剧后,杰克·谢帕德这一角色本该在坠机事件中遇难,接着将由凯特在这部剧中担任更多的领导角色。

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

Think you’ve had some bad job interviews this year? This survey is guaranteed tcheer you up (unless you happen tbe part of it). When staffing firm OfficeTeam asked 600 managers across North America tdescribe the most embarrassing interview blunders they had seen in 2014, here’s what they said.
The world got by in 2013 with fewer confidence-shaking moments than in prior years. But the vulnerabilities haven't disappeared. 'It's not a great story anywhere, though it's more hopeful than it has been,' said Jerry Webman, chief economist at OppenheimerFunds.

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

完成家庭作业,阅读指定的内容,以及其他的事。在网络上查找关于你的学习主题的内容,在图书馆看看书,再看看还可以学到哪些关于主题的内容。

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

10.你真的很明显,好吧?
汤姆汉克斯和梅丽尔斯特里普出演,史蒂文斯皮尔伯格执导,这样一个为新闻自由而战的历史故事,有很多让评委刮目相看的地方。
The Journey of Flower

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

entertainment
你咋不上天呢?
Swyft有50家短信应用合作伙伴,包括Kakao Talk, Facebook Messenger, BlackBerry Messenger和 Line。这种合作让这家只有11个人的小公司能接触到25亿注册用户。随着利用短信应用赚钱的办法不断演化,这家年轻的创业公司已探索出一条可让各大品牌挤进人们聊天领域的生财之道。(财富中文网)
《X战警:天启》据悉将于2016年5月27日上映。

Graphical abstract: Length-scale dependence of protein hydration-shell density
From the themed collection: 家居建材消费投诉升温
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

净利差——即贷款和存款的利率之差——在降低,因为中国撤销了对存款利率的剩余管制。2015年,中国银行业平均利差下降约46个基点,至2.54%。
项目长度:22个月

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

n. 代表,副手
在2017年FT对全球95个管理学硕士项目的排行中,虽然瑞士圣加仑大学(University of St Gallen)继续蝉联冠军,但法国和英国商学院分别以24个和18个项目入围成为中坚力量。超过一半的英国商学院排名上升,而只有一家法国商学院排名上升。三分之一的英国商学院排名上升5位,相比之下,三分之二的法国商学院排名下降5位或更多。
维多利亚的秘密内衣秀刚刚拉开华丽巨幕,今年的秀也是有史以来最奢华复杂的一次。

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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championship
此外,他还刷新了他职业新高的助攻数、2分球命中率(63%),还有同样为职业生涯最高的78.5%的罚球命中率。而且,他这赛季的篮板数比职业生涯平均篮板数也多了0.4个。总而言之,詹姆斯本赛季在除得分以外,各项数据都是堪称亮眼。

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